Esculin, Esculoside, Asculin


Esculin, Esculoside, Asculin substance is a product of a coumarin derivative extracted from the bark of flowering ash (Fraxinus ornus). Esculin substance is used in the manufacturing of pharmaceuticals with venotonic, capillary- strengthening and antiphlogistic action similar to that of Vitamin P.

Item # EB2030-10313

Description: The substance is a product of a coumarin derivative extracted from the bark of flowering ash (Fraxinus ornus). Esculin substance is used in the manufacturing of pharmaceuticals with venotonic, capillary- strengthening and antiphlogistic action similar to that of Vitamin P.

Molecular mass: 340.28 (anhydrous substance) and 367.31 (of crystalline water)

Physicochemical indices of the finished product

¤ Appearance crystalline powder
¤ Color white to light-creamy
¤ Taste bitter
¤ Odor odorless
¤ Melting temperature (°C) approximately 240.0 (with disintegration)
¤ Successive melting temperatures (°C) 155.0; 204.0; 212.0
¤ Solubility  
in water (20°C) poorly soluble
in alcohol (20°C) poorly soluble
in methanol (20°C) poorly soluble
in hot alcohol soluble
in hot methanol soluble
in hot pyridine soluble
in hot dioxane soluble
¤ Moisture content according to K. Fisher (%) 6.5 - 8.0
¤ Sulfate ash (%) not more than 0.1
¤ Heavy metals content (%) not more than 0.004
¤ Limpidity of solution need to meet standard No 5
¤ Specific rotation (°) from -84.0 to -87.0
(2% solution of anhydrous esculin (wt/v) in 50% dioxane solution  
¤ Extinction coefficient (µm) from 0.340 to -0.360
(0.0015% solution in methanol)  
¤ Particle size (µm) min 95.0 - 180.0
¤ Esculin content calculated as dry substance (%) not less than 98.0
¤ Microbial content  
Total microorganisms (number/g) not more than 10-3
Moulds and yeast (number/g) not more than 10-2
Enterobacteriaceae, Ps. aeruginosa, St. aureus not allowed

Supplied: The substance is filled in double polyethylene bags of 25 kg and placed in cardboard barrels.

Standard: IX French Pharmacopoeia

Expiration term: Four years

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