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Nivalin (Galantamine) at

For complete information on Nivalin: addresses various clinical topics on Nivalin (Galantamine): Galantamine and the adrenal glands, safety and toxicity, mutagenicity of Galantamine, clinical application.

Excessive Decurarizing Drug

Nivalin Galantamine source plant Galantus Nivalis

Nivalin is an original phytopreparation developed by Sopharma's own research team and produced with an original technology for extraction of the alkaloid Galantamine from the bulbs of the plant snowdrops (Leucojum aestivum). Galantamine is the active ingredient in Nivalin.

Nivalin, Galantamine mechanism of action

Nivalin is competitive reversible inhibitor of Acetylcholinesterase (AChE) and prolongs the hydrolysis of endogenous mediator acetylcholine, thereby increasing its accumulation in the choline sensitive postsynaptic membranes.

Sopharma offers Nivalin as:

Ampoules of 1 ml in the concentrations of 1 mg; 2.5 mg; 5 mg and 10 mg. Tablets in concentrations of 5 mg in package of 60 count and 10 mg in package of 20 count.

Nivalin Anticholinesterase activity

Nivalin Galantamine source plant Galantus Nivalis

Nivalin inhibits reversibly brain, erythrocytic, muscle and serum cholinesterase. Its effect on brain cholinesterase is 10-12 times as potent, compared to physostigmine, since Nivalin crosses the blood-brain barrier.

  • Nivalin increases the intensity of nerve impulses leading to the muscle tissues, increases muscle contractions and their duration.
  • Nivalin antagonizes the effect of nondepolarizing neuromuscular blocking drugs. The antagonistic effect develops 20-30 s following parenteral administration and continues 30 to 60 minutes.
  • Nivalin stimulates the frequency and tone of the gastrointestinal muscle contraction.
  • Nivalin possesses mild hypotensive effect when administered in small or medium doses and in higher doses has two-phase action.

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