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NIVALIN, GALAMTAMINE AN ALKALOID WITH ANTICHOLINESTERASE ACTIVITY !
NIVALIN (GALANTAMINE) ALKALOID WITH ANTICHOLINESTERASE ACTIVITY
Excessive Decurarizing Drug
Nivalin is an original phytopreparation developed by Sopharma's own research team and produced with an original technology for extraction of the alkaloid Galantamine from the bulbs of the plant snowdrops (Leucojum aestivum). Galantamine is the active ingredient in Nivalin.
NIVALIN (GALANTAMINE) MECHANISM OF ACTION
Nivalin is competitive reversible inhibitor of Acetylcholinesterase (AChE) and prolongs the hydrolysis of endogenous mediator acetylcholine, thereby increasing its accumulation in the choline sensitive postsynaptic membranes.
Adaptation of nicotine cholinesterase transmission for account of the blockage of AChE and the sensibilization of nicotine acetylcholine receptors (nAChR).
Nivalin inhibits reversibly brain, erythrocytic, muscle and serum cholinesterase. Its effect on brain cholinesterase is 10-12 times as potent, compared to physostigmine, since Nivalin crosses the blood-brain barrier.
NIVALIN IN NEUROLOGY NIVALIN IS APPLICABLE IN:
NIVALIN IS APPLICABLE AS WELL IN:
RECOMMENDED DOSAGE SCHEMES:
|Age||Appropriate doses||Appropriate doses|
|From 1 to 2 years of age:||0.25 - 1.0 mg|
|From 3 to 5 years of age:||0.50 - 5.0 mg|
|From 6 to 8 years of age:||0.75 - 7.5 mg||5 - 10 mg|
|From 9 to 11 years of age:||1.00 - 10.0 mg||5 - 15 mg|
|From 12 to 15 years of age:||1.25 - 12.5 mg||5 - 25 mg|
|Over 15 yeas of age of age:||12.50 - 15.0 mg||10 - 40 mg|
A treatment course continues for 1 - 2 months and in degenerative diseases of the Central Nervous System up to one year.
Nivalin is a preparation with low toxicity, soft and stable action and possesses wide spectrum of application for therapeutic purposes.
Nivalin is very well tolerated and despite that fact should not be prescribed in conditions of bronchial asthma, bradycardia, angina pectoris, heart failure, epilepsy, hyperkinetic dyskinesia.
SOPHARMA OFFERS NIVALIN IN THE FOLLOWING FORMS:
Ampoules of 1 ml in the concentrations of 1 mg; 2.5 mg; 5 mg and 10 mg
Tablets in concentrations of 5 mg in package of 60 count and 10 mg in package of 20 count.