QUIT SMOKING WITH TABEX!
TABEX FOR CLEAN LUNGS, FOR A HEALTHY HEARTH!
Tabex is an original Bulgarian drug of vegetal origin for treatment of nicotinism. It is developed on the basis of the alkaloid contained in the plant Citisus laborinum L., also called Golden Rain, widespread in the southern areas of Central Europe and Italy. All parts of the plant contain the alkaloid cytisine, the greatest amount (up to 3%) being found in the seeds.
Fig. 1 Structural formula of cytisine
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(1R-cis)-1,2,3,4,5,6-hexahidro-1,5-metano-8h-pyrido[1,2a][1,5]diazocin-8-on
Chemical characteristics and content of Tabex
Each tablet contains 0.0015 g cytisine
Empirical formula of cytisine: C11H 14ON 2
Ensuing from the molecular orbital calculations after Kier(1969), it is
evident that the molecular configurations of nicotine and acetylcholine
have a quaternary nitrogen atom which is with a negative charge and
located at 4.85 +/- 0.1 A, considered to be responsible for the
nicotine-like activity. In cytisine the nitrogen atom in ring C appears at
4.8-9 A from the oxygen atom of the pyridine group and is also negatively
charged.
The prolonged clinical and toxicological studies in many countries all
over the world have proved the enormous harm of smoking on all organs and
systems of the human organism. The danger of cardiovascular incidents
(myocardial infarction, stenocardia, peripheral vascular diseases),
diseases of the respiratory system (lung cancer, tracheobronchitis, etc.),
as well as psychic and physiological dependence of addictive type is
mostly emphasized.
Fig. 2 Stereoisomeric formulae of cytisine and nicotine (after Barlow, R.B. and McLeod, L.J.)
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The treatment of nicotine addiction is a complex process in which drug therapy occupies an important part. Sopharma produces the drug Tabex, developed on the basis of the alkaloid cytisine, which has an action similar to that of nicotine.