| Item # EB2030 103-13 DESCRIPTION: The substance is a product of a coumarin derivative extracted from the bark of flowering ash (Fraxinus ornus). Esculin substance is used in the manufacturing of pharmaceuticals with venotonic, capillary- strengthening and antiphlogistic action similar to that of Vitamin P. | MOLECULAR MASS: | 340.28 (anhydrous substance | | | 367.31 (of crystalline water) |
PHYSICOCHEMICAL INDICES OF THE FINISHED PRODUCT | ¤ Appearance | crystalline powder | | ¤ Color | white to light-creamy | | ¤ Taste | bitter | | ¤ Odor | odorless | | ¤ Melting temperature (°C) | approximately 240.0 (with disintegration) | | ¤ Successive melting temperatures (°C) | 155.0; 204.0; 212.0 | | ¤ Solubility | | in water (20°C) | poorly soluble | in alcohol (20°C) | poorly soluble | in methanol (20°C) | poorly soluble | in hot alcohol | soluble | in hot methanol | soluble | in hot pyridine | soluble | in hot dioxane | soluble | | ¤ Moisture content according to K. Fisher (%) | 6.5 - 8.0 | | ¤ Sulfate ash (%) | not more than 0.1 | | ¤ Heavy metals content (%) | not more than 0.004 | | ¤ Limpidity of solution | need to meet standard No 5 | | ¤ Specific rotation (°) | from -84.0 to -87.0 | | (2% solution of anhydrous esculin (wt/v) in 50% dioxane solution | | | ¤ Extinction coefficient (µm) | from 0.340 to -0.360 | | (0.0015% solution in methanol) | | | ¤ Particle size (µm) | min 95.0 - 180.0 | | ¤ Esculin content calculated as dry substance (%) | not less than 98.0 | | ¤ Microbial content | | Total microorganisms (number/g) | not more than 10-3 | Moulds and yeast (number/g) | not more than 10-2 | Enterobacteriaceae, Ps. aeruginosa, St. aureus | not allowed |
SUPPLIED: The substance is filled in double polyethylene bags of 25 kg and placed in cardboard barrels. STANDARD: IX French Pharmacopoeia EXPIRATION TERM: Four years |