International generic name
Drug form and composition
Solution for injection. One ampoule Xylodren (blue) of 2 ml contains: 40 mg Lidocaine hydrochloride; 0.04 mg Epinephrine; 0.04 mg Norepinephrine. One ampoule Xylodren (brown) of 2 ml contains: 40 mg Lidocaine hydrochloride; 0.025 mg Epinephrine. One ampoule Xylodren (green) of 2 ml contains: 40 mg Lidocaine hydrochloride; 0.1 mg Norepinephrine.
The product is used in dentistry for induction of conduction anesthesia.
Dosage and administration
For induction of conduction anesthesia 1 - 2 ampoules are used for infiltration of the tissue. The anesthesia develops after 5 - 10 minutes and lasts approximately 1 - 2 hours.
Hypersensitivity to some of the product ingredients; myasthenia gravis; severe cardiovascular insufficiency; hyperthyroidism; arterial hypertension; methemoglobinemia; vascular disturbances.
Special warnings and precautions
The product should be used with caution in elderly patients suffering form cardiovascular, renal, and liver diseases; in hyperthermia, and hypotension. Xylodren (green), which contain only norepinephrine as a vasoconstrictor agent is the best choice in patients with unstable hemodynamics. Xylodren (brown) and Xylodren (blue), which contain, as a vasoconstrictor epinephrine are not appropriate in patients with unstable hemodynamics. This product should be avoided during the first trimester of pregnancy and should be used with caution during the other periods of pregnancy and during lactation. After the dental procedure increased caution is necessary in activities, like car driving or working with machines.
In cases of concurrent administration of Xylodren with β-adrenoblockers, hypotension, bradicardia, and bronchospasm can develop. It decreases the cardiotonic effect of digitoxin. When used concurrently with curare-like agents, there is a risk of paralysis of the respiratory muscles. Lidocain activity decreases to a great extent in an acid environment (focus of inflammation), in uremia, and in cases of concurrent administration with dextrose and calcium preparations. The effect increases and prolongs by analgesics, tranquilizers and general anesthetics.
In sensitive patients, allergic reactions and visual disturbances can be observed.
Xylodren is a topical anesthetic, containing lidocaine and varying concentrations of the vasoconstrictors epinephrine and norepinephrine. It provides a fast, strong, and prolonged anesthetic effect. Lidocain exerts local anesthetic action, stronger than that of procain. It possesses a membrane stabilizing activity. Lidocain inhibits mainly the influx of the sodium ions and to a lesser extent the eflux of the potassium ions through the neuronal membranes. It also blocks binding of the calcium ions to their receptors. At the place of application the passability of the neuronal membrane decreases and the depolarization is inhibited. Added epinephrine and norepinephrine cause local vasoconstriction and reduce lidocaine absorption.
10 or 50 ampoules of 2 ml.