International generic name Combined product
Drug form and composition Coated tablets. One coated tablet contains 20 mg Peflavit and 50 mg Ascorbic acid.
Indications Peflavit C is indicated, as a part of the complex therapy, in following diseases: hemorrhagic diathesis and capillary disorders due to different causes; diseases manifesting with decreased capillary resistance and increased capillary permeability, including acute and chronic glomerulonephritis, chronic hepatitis, rhinitis, laryngotracheitis, pneumonia, dermatitis, retinal hemorrhage, inflammatory and degenerative diseases of the veins and joints, atherosclerosis, hypertension, and infectious diseases.
Dosage and administration 1 tablet, 3-4 times daily; in severe cases 2-3 tablets, 3-4 times daily. The treatment is usually continued from several days to 1 month, depending on the disease and the clinical manifestations.
Contraindications The preparation should not be used in hypersensitivity to any of its ingradients; in patients with prosthetic cardiac valves; in persons, taking an anticoagulant therapy; in glucoso-6-phosphate dehydrogenase insufficiency; nephrolythiasis; thalasemia.
Special warnings and precautions The preparation should be used with care in persons with hypercoagulability, thrombophlebitis and propensity to thrombosis. It should be used with care in patients with diabetes also. The preparation should not be taken with meal, as it destructs vitamin B12 in the gastrointestinal tract. The preparation should be used with care in pregnant and nursing women.
Drug interactions The preparation should be used with care in persons with hypercoagulability, thrombophlebitis and propensity to thrombosis. It should be used with care in patients with diabetes also. The preparation should not be taken with meal, as it destructs vitamin B12 in the gastrointestinal tract. The preparation should be used with care in pregnant and nursing women.
Adverse reactions Concomitant treatment with barbiturates reduces elimination of the latter, their plasma concentrations are elevated and their pharmacology activity is increased. Bioflavones are recommended in salicylate and arsenic compound overdosing. Peflavit C could be combined with other capillarotonic preparations.
Pharmacological mechanisms The preparation is very well tolerated and adverse reactions are very rare. In high doses the preparation may cause hypercoagulation and propensity to thrombosis.
The combined preparation Peflavit C possesses the effect of the condensed catechines in the St. John’s worth, and this of the ascorbic acid. St. John’s worth composites, being bioflavones, possess a capillarotonic effect and reduce the vascular wall permeability, from other hand, they possess some anti-inflammatory action. Ascorbic acid, being an antioxydant vitamin, potentiates the effects of bioflavones by activating the cell metabolism. It exerts a regulatory effect on the oxygenation processes in the cells, participating in the redox-systems as a universal catalyst. This leads to normalization of the tissue metabolism, coagulation, reticulo-endothel function and erythropoiesis. Peflavit C possesses powerful detoxifying and desensitization effects. Supplied 60 coated tablets. Expiry 24 months |