International generic name

Sodium citrate

Drug form and composition

Auxiliary solution for laboratory needs. One ampoule of 1 ml (3.8%) contains 31 mg Sodium citrate with 2 molecules crystalline water, equivalent to 38 mg Sodium citrate with 5.5 molecules crystalline water. One ampoule of 5 ml (5%) contains 205 mg Sodium citrate with 2 molecules crystalline water, equivalent to 250 mg (50 mg/ml) Sodium citrate with 5.5 molecules crystalline water.

Indications

Sodium citrate with a concentration 3.8% is used in blood coagulation for clinical laboratory examinations. Sodium citrate with a concentration 5% is applied as a symptomatic drug in nausea and vomiting.

Dosage and administration

Sodium Citrate 3.8% is used in the clinical laboratory examinations usually in a ratio of 1:9 (1 part Sodium citrate to 9 parts blood). Sodium citrate 5% is applied in the following doses: Adults - 2-3 g, 3-4 times daily. Children: up to 3 months - 0.05 g; 3 to 6 months - 0.10 g; 6 to 12 months - 0.25 g; 2 to 3 years - 0.30 g; 4 to 7 years - 0.50 g; 8 to 14 years - 1-2 g, 3-4 times daily.

Contraindications

It is not applied in supersensitivity to the preparation.

Special warnings and precautions

Ampoules with changed transparency of solution should not be used.

Drug interactions

Unfavorable interactions with other drugs are unknown.

Adverse reactions

There is a danger of hypernatriemia in injured renal function or hyperaldesteronism.

Pharmacological mechanisms

Sodium citrate (3.8%), applied for laboratory needs, combines ionized calcium in non-dissociation form. Added to blood “in vitro”, it prevents its coagulation. Sodium citrate (5%) applied orally, relaxes the stomach mucosa and exerts antiemetic effect in reflex vomiting, as well as a soft purgative action on the stomach.

Supplied

10 or 50 ampoules of 1 ml (31 mg ) and 5 ml (205 mg).

Expiry

Auxiliary solution for laboratory needs and peroral solution - 5 years.