International generic name
Sodium bromide
Drug form and composition
Solution for injection. One ampoule of 5 ml (10 %) contains 500 mg (100 mg/ml) Sodium bromide.
Indications
The preparation is indicated in acute neurosis (neurasthenia, hysteria); exacerbated ulcer disease.
Dosage and administration
Natrium bromatum is applied intravenously in dose 0.5-1 g (5-10 ml), 10% solution for injection.
Contraindications
The preparation should not be used in following conditions: hypersensitivity; tuberculosis; generalized atherosclerosis; cachexy and malnutrition; severe dehydration; gastrointestinal diseases, accompanied with vomiting and diarrhea; nephritis; allergic rhinitis; dermatitis; convulsions in acute strychnine intoxication; tetanus; pregnancy and lactation.
Special warnings and precautions
Long-term treatment requires large amount liquids and salt (10-20 g daily) consumption. During the treatment is necessary the gastrointestinal function monitoring. The preparation should not be given to drivers and machinery operating persons, as it retards and depresses the reflector function and exerts negative influence on the visual and auditory nerves.
Drug interactions
Bromide ions displace the chlorine ions in the central nervous system. Due to the latter a saltless diet during the treatment with potassium bromide may enhance its action. The excretion of the preparation in urine is increased by concomitant administration of hypertonic solutions of sodium chloride and saluretics. The preparation could be combined with other sedative preparations, coffeine and atropine.
Adverse reactions
The application of Natrium bromatum may cause following adverse reactions: bromide acne; vomiting; diarrhea; body weight reduction; apathy; torpidity; walk disorders; visual and auscultatory disorders; mental disorders; reduction of the libido.
Pharmacological mechanisms
Bromide ions reduce the spontaneous and reflector excitation of the CNS and vegetative nervous systems by selective enhancement of the suppression process in the brain. They possess an anticonvulsive effect also. The mechanism of Natrium bromatum action is explained by displacement of the chlorine ions by the bromide ones in the intercellular spaces in CNS. Natrium bromatum is excreted in the mother milk, sweat and bronchial secretion, and in long-term administration cumulates in tissues.
Supplied
10 or 50 ampoules of 5 ml (10%).
Expiry
5 years. |