International generic name

Glucose anhydrious

Drug form and composition

Solution for injection. One ampoule of 10 ml contains 1 g (10%); 2 g (25%) or 4 g (40%) Glucose anhydrious.

Indications

The solution is applied in pulmonary edema, brain hemorrhage, uremia, acute infections.

Dosage and administration

The preparation is applied intravenously in quantities relevant to the particular case. In adults the maximal dose is 28 ml/kg/24 hours.

Contraindications

The solution should not be applied in diabetes, hypokalemia, hyperhydration, hypotonic dehydration, acidosis, and renal failure.

Special warnings and precautions

Before administration of the hypertonic solutions glucose serum level should be investigated.

Drug interactions

Concomitant administration with adrenalin and narcotics prologs their action.

Adverse reactions

Intravenous application of hypertonic glucose solutions may cause local irritation of the vascular wall. In long-term administration hypophosphatemia may appear.

Pharmacological mechanisms

Glucose is a carbohydrate alimentary substance, which after oxidation is transformed to the basic energy source. In this manner is provided energy for the functioning of the nervous and cardiovascular system, skeletal muscles and all intensive functioning organ cells. Intravenous application of isotonic (4.5-5%) solution acts as a plasma substitute. Hypertonic solution injecting extracts fluids from the tissues, including areas with transudate and exudate; improves the metabolism; improves the detoxication function of the liver; improves contractility of the heart muscle; causes vasodilatation and increase diuresis. The 40% hypertonic solution facilitates blood coagulation and reduces nitric substances loss in febrile conditions. It causes denaturation of the proteins and in this manner acts as a nonspecific protein stimulant of the reticular endothelia.

Supplied

50 ampoules of 10 ml.

Expiry

3 years.