International generic name Combined product
Drug form and composition Syrup. 5 ml Syrup contains: 10 mg Diphenhydramine hydrochloride; 100 mg Ammonium chloride.
Indications In imitative and spastic cough; cough in inflammatory diseases of the upper respiratory tract; acute and chronic bronchitis; tracheobronchitis.
Dosage and administration In children the dosage is as follows: children 1-3 years -2.5 ml 3-4 times daily; 4-8 years - 2.5-5 ml 3-4 times daily; 9-14 years - 5 ml 3-4 times daily. In adults and children older than 14 years - 10 ml 3-4 times daily. The treatment usually continues 8-10 days; if necessary the treatment may be prolonged to 25 days.
Contraindications Hypersensitivity to diphenhydramine; acute asthmatic attacks; narrow-angle glaucoma; prostatic gland adenoma and uretheral stenosis, causing urine retention; stenotic peptic ulcer; pregnancy and lactation; children younger than 1 year.
Special warnings and precautions Dimex should be used carefully in patients with bronchial asthma because it impedes secretion elimination. In infants antihistamine preparations (mainly in overdosage) may cause hallucinations, convulsions, and excitation. It should be used with caution in elderly persons, as it may provoke dizziness, somnolence, and arterial hypertension. The preparation should be used with caution in driving persons. During the treatment alcohol consumption is undesirable.
Drug interactions Dimex potentiates effects of the hypnotic and sedative drugs, anxiolytics, tricycle antidepressants, MAO-inhibitors, general anesthetics, alcohol and other suppressing CNS agents.
Adverse reactions Somnolence; attention disorders; xerostomia; hypotension; constipation; gastrointestinal manifestations, including nausea and vomiting. Photoallergy reactions and muscle dystonia were seen.
Pharmacological mechanisms An antitussive medicine free of opiates. The main ingredient of the preparation is diphenhydramine (H1-blocker), possessing prominent anti-cholinergic and sedative effects. Its powerfull anti-cholinergic effect (M-cholinolytic) explains reduction of the bronchial secretion and the spasmolytic effect of the drug. These effects are related to its H1 - blocking activity. The antiemetic effect of diphenhydramine is due to H1 - histamine receptors blocking in the vestibular nuclei, nucleus tractus solitarii and other brain structures. Ammonium chloride possesses a secretomotor activity - stimulates the respiratory tract epithelial cilia movement (confirmed experimentally), directed to the mouth, and facilitates expectoration. It exerts some stimulating action on the respiratory center, which improves the expectoration-stimulating effect.
Supplied Vials, containing 125 ml syrup.
Expiry 3 years. |