International generic name Meclofenoxate
Drug form and composition Powder for solution for injection and solvent. One ampoule of 10 ml contains 250 mg Meclofenoxate hydrochloride (powder for solution for injection). One ampoule of 10 ml contains 10 milliliters Sterilised water for injections (solvent).
Indications The preparation is indicated in following conditions: comma; skull and brain trauma; following a stroke; encephalopathy; mental disorders (in combination with psychotropic agents); mental and psychomotor retardation in children; brain intoxication; alcohol psychoses; neuritis and polyneuritis.
Dosage and administration The preparation is administered intravenously, subcutaneously and intramuscularly, most frequently as a single dose of 250 mg (1 ampoule). The powder is diluted just before injection. Depending on the patient condition the dose may reach 1-2 g/24h. Duration of the treatment depends on the severity of the disease and should be determined by the doctor.
Contraindications Hypersensitivity to the preparation; infection of the CNS; epilepsy; neuroses presenting with intension and phobia; renal and hepatal insufficiency.
Special warnings and precautions In patients with severe arteriosclerosis and in elderly patients the preparation should be used with care, as a risk of significant agitation exists. The medicine should be administered in pregnant and nursing women only if serious indication exist and on doctor’s decision.
Drug interactions Centrophenoxin is used as a basic therapy in mental disorders. In such cases it is combined with psychotropic agents (antipsychotics, anxiolytics, and antidepressants). In the clinic practice Centrophenoxin is successfully combined with antiepileptic and anti-Parkinson’s disease medicines. In cases with alcohol and CNS - depressing agents intoxication Centrophenoxin exerts a detoxication effect. In concomitant treatment with psychoanaleptics an increase of CNS excitation may appear.
Adverse reactions In isolated cases in predisposed patients, particularly in elderly persons, the preparation may provoke excitation, aggression, insomnia, and headache. In patients with paranoid symptoms and hallucinations the preparation may lead to worsening of the condition. In some cases skin allergy and gastrointestinal disorders may appear.
Pharmacological mechanisms Centrophenoxin belongs to the group of psychostimulants - nootropic agents, which possess an activating action on the brain, improving the neural cell metabolism. Centrophenoxin stimulates the aerobic glycolysis and leads to improvement of the glucose utilization in the brain cells. It improves the brain cell stability to hypoxia and toxic agents or their metabolites. In long-time use the preparation recovers the functionally injured brain cells.
Supplied 5 ampoules of 10 ml (250 mg) containing powder for solution for injection, and 5 ampoules of 10 ml containing solvent.
Expiry 4 years. |