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INSULIN LENTE S
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Product description |
| EB0280-445-05 |
INSULIN
LENTE S VIAL 10 ML 10 IU/1 ML |
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- COMPOSITION:
Insulin from procine pancreas - 40 IU/l ml suspension.
ACTION:
Insulin is a polypeptide hormone which participates in the
regulation of carbohydrate, fat and protein metabolism. It increases
the transport of glucose through the plasma membranes of cells,
muscles, heart, fatty tissue and WBC, stimulates its oxidation and
increases the synthesis and the cumulation of glucogen in the liver
and muscles. Insulin stimulates the inclusion of the fatty acids
into Kreb's cycle, increases the triglyceride depots in fatty tissue
and decreases the formation of ket-bodies. The changes in
carbohydrate metabolism are characterized by prevalence of the
anabolic processes. Insulin realizes its numerous effects by binding
to the specific Insulin receptors with membrane localization.
Insulin Lente is an intermediate insulin with retarded initial
effect, but with prolonged hypoglycemic action lasting from 16 to 24
h, depending on the individual particularities of the carbohydrate
metabolism of each patient. Insulin Lente is well tolerated and has
no expressed immunogeny.
PHARMACOKINETICS:
It is absorbed slowly and its effect begins 1-1,5 h after
application, the maximum effect being observed after 10-12 h.
INDICATIONS:
Diabetes mellitus in compensated stage. In case of allergy or
resistance towards bovine Insulin preparations.
CONTRAINDICATIONS:
Comatose conditions of different origin, precomatose conditions and
diabetic ketose. Insulin preparations with prolonged action should
not be applied during surgical interventions and delivery.
SIDE EFFECTS:
Lipodystrophy or transitory edema at the place of application, if
the place of injection is not changed. Allergic reaction of
"immediate type" (erythema, eruption, itching) may be
observed very rarely. |
DRUG INTERACTIONS:
The hypoglycemic action of insulin decreases when it is applied
simultaneously with glucagon, adrenomimetics, betablockers,
phenothiazine derivatives, salicylates, butaldion, glucocorticoids,
preparations from the posterior part of the hypophysis, gas
narcotics, thiazid diuretics and furosemid, while ipsarid,
clofibrate, ethyl alcohol and oral antidiabetic drugs increase it.
Insulin enhances the antituberculosis action of PAS. Insulin and
strophantine have a contrary action on the metabolism and
contractility of the myocardium, that is why a mutual reduction and
even conversion of their effects may be observed.
PRECAUTIONS:
Hypoglycemia may occur during treatment as a result of heavy
physical loads, in case of irregular meals, vomiting, nephropathy in
advanced stage, decreases function of the thyroid and pituitary
glands, as well as after application of higher doses or increased
sensitivity towards insulin. Each patient must be informed about the
main symptoms of hypoglycemia - headache, strong perspiration, sleep
disturbances, speech and vision disturbances, and psychic
disturbances with depressive character up to loss of consciousness.
In case the hypoglycemia, the patient must take immediately
sweetened tea or sugar. The hypoglycemic coma is treated with 40%
glucose solution i.v., in severe cases of 1 ml of 0.1% solution of
adrenalin of glucagon may be applied subcutaneously.
DOSAGE AND ADMINISTRATION:
The treatment with insulin depot-preparations must always begin
under doctor's control, based on the data of the blood sugar profile
and the calculations of the carbohydrate balance. The preparation is
applied subcutaneously, the daily dose of each patient being
determined individually. Before use, the vial must be shaken
thoroughly and the suspension should be injected immediately after
aspiration.
Different Insulin preparations should not be mixed in one syringe
because of the different pH of the solutions.
MEDICINAL FORM AND PACKAGE:
Suspension in vials of 10 ml.
STORAGE:
At temperature 2-8° C.
DO NOT FREEZE!
EXPIRY:
2 (two) years.
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