INSULIN NS
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| StockNo |
Product description |
| EB0280-445-04 |
INSULIN
NS VIAL 10 ML INJECTION SOLUTION |
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- COMPOSITION:
Insulin from porcine pancreas 40 IU/ml injection solution.
ACTION:
Insulin is a polypeptide hormone, which participates in the
regulation of carbohydrate, fat and protein metabolism. It increases
the transport of glucose through the plasma membranes of cells,
muscles, heart, fatty tissue and WBC, stimulates its oxidation and
increases the synthesis and the cumulation of glycogen in the liver
and muscles. Insulin stimulates the inclusion of the fatty acids
into Kreb's cycle, increases the triglyceride depots in fatty tissue
and decreases the formation of keto-bodies. The changes in
carbohydrate metabolism are characterized by prevalence of the
anabolic processes. Insulin realizes its numerous effects by binding
to the specific insulin receptors, which have membrane localization.
PHARMACOKINETICS:
It is absorbed quickly and rarely causes local and general allergic
reactions. The action of the preparation begins 15-20 min after
application and lasts 6 h on the average.
INDICATIONS:
Insulin-dependent diabetes mellitus and its complications (diabetic
coma and precoma). Shock insulin therapy in psychoses.
CONTRAINDICATIONS:
Allergy towards insulin. The preparation is contraindicated in
slight forms of diabetes with tendency to hypoglycemia.
SIDE EFFECTS:
Weakly expresses hypoglycemic reactions due to its quick absorption.
Lipodistrophy or transitory edema at the place of application if the
place of injection has not been changed. Allergic reaction of
'immediate type" (erythema, eruption, itching) may be observed
in very rare cases. |
DRUG INTERACTIONS:
The hypoglycemic action of Insulin decreases when it is applied
simultaneously with glucagon, adrenomimetics, betablockers,
phenothiazine derivatives, salicylates, butadion, glycocorticoids,
preparations from the posterior part of hypophysis, gas narcotics,
thiazide diuretics and urosemid, while iprasid, clofibrate, ethyl
alcohol and oral antidiabetic drugs increase it. Insulin enhances
the antituberculosis action of PAS.
Insulin and strophantine have a contrary action on the metabolism
and contractility of the myocardium, hence a mutual reduction and
even inversion of their effects are possible.
PRECAUTIONS:
Hypoglycemia may occur as a result of heavy physical loads, in cases
of irregular meals, vomiting, nephropathy in advanced stage, chronic
hepatic diseases, Addison's disease, decreased function of the
thyroid and pituitary glands, as well as after a higher dose or
hypersensitivity to insulin. Every patient must be informed about
the main symptoms of hypoglycemia - headache, strong excitability,
restlessness, stupor, bulimia, tremor, increased perspiration, sleep
disturbances, speech and vision disturbances, psychic disturbances
with depressive character up to loss of consciousness.
In case of hypoglycemia, the patient must take immediately sweetened
tea or sugar. The hypoglycemic coma is treated with 40 % glucose
solution i.v., in severe conditions 1 ml of 0.1 % solution of
adrenalin or glucagon may be also applied.
DOSAGE AND ADMINISTRATION:
The treatment with Insulin NS should always begin under physician
control. The preparation is applied subcutaneously, intramuscularly
or intravenously, and is dosed individually on the basis of the data
of the blood sugar profile and the calculations of the carbohydrate
balance. Before use the vial should be shaken and the suspension
should be injected immediately after aspiration into the syringe.
MEDICINAL FORM AND PACKAGE:
Injection solution in vials of 10 ml.
STORAGE:
At temperature 2-8° C.
DO NOT FREEZE!
EXPIRY:
2 (two) years.
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