PRENYLAMIN
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| StockNo |
Product description |
| EB0280-424-19 |
PRENYLAMIN
DRAGEE X 10 |
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- COMPOSITION:
Prenylamine lactate 15 mg, 30 mg and 60 mg in one dragee
ACTION:
The drug dilates the coronary vessels. It is assumed to act as
calcium antagonist, but has no substantial effect on the
contractility of the myocardium. It improves the vascular blood
circulation, oxygen supply of the myocardium, increases its oxygen
reserves and the concentration of ATP, creatinin, adenosine
nucleotide and glycogen. It reduces the content of norepinephrine
and serotonin in the myocardium and brain. It has a light blocking
effect on beta-adrenergic receptors, about 50 % weaker than that of
Propranolol. It reduces the peripheral vascular resistance and can
induce a moderate blood pressure drop. In high doses and in cases of
tachycardia, it leads to deceleration of cardiac activity.
INDICATIONS:
Treatment of chronic coronary insufficiency and prophylaxis of
anginal paroxysms; disturbances in brain blood circulation,
hypertension, cor pulmonale. It is not sufficiently effective in
acute angional paroxysms.
CONTRAINDICATIONS:
Snock. Cardiac conduction disturbances (grave atrioventicular and
intraventicular disturbances). |
SIDE EFFECTS:
Rarely dyspeptic disturbances (nausea, vomiting, diarrhea). Skin
allergic reactions, quickly abating after discontinuation of the
treatment. Parkinson-like tremor can be observed during a long-term
course. It is not well tolerated by patients with hypotension and
pronounced cardiosclerosis.
PRECAUTIONS:
High doses should not be taken by drivers and by persons performing
activities associated with concentration of attention, as the latter
is failing and fatigue is likely to occur. It should not be
prescribed to patients with advanced cardiac defect prior to their
digitalization. Do not prescribe to children and keep the drug out
of their reach (300 mg cause convulsions).
DRUG INTERACTIONS:
It enhances the antihypertensive effect of betablockers, hence their
dose should be decreased.
DOSAGE AND ADMINISTRATION:
Prscribed in 0.015-0.03 g per intake, 2-3 times daily; in more
severe cases - 0.06-0.12 g, 2-3 intakes (i.e. 0.06 g prenylamin
gragees).
MEDICINAL FORM AND PACKAGE:
Packages of 10 dragees.
STORAGE:
At moderate temperature (15-30° C).
EXPIRY:
3 (three) years.
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