CHLOPHAZOLIN
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| StockNo |
Product description |
| EB0280-424-06 |
CHLOPHAZOLIN
AMPOULE 0.15 MG/1 ML (0.015%) |
| EB0280-424-30 |
CHLOPHAZOLIN
TABL 0.15 MG X 50 |
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- COMPOSITION:
Clonidine 0.15 mg/l ml in one ampoule and
0.15 mg in one tablet
ACTION:
A derivative of imidazoline, and similar to the other drugs from
that group it has an effect on the adrenoreactive system. Its
antihypertensive effect is determined by the stimulation of
alpha-2-adrenoreceptors in nucleus tractus solitari, which leads to
decreased peripheral sympathetic tone. It reduces the venous reflux
and the renin level. The drug has no effect on the synthesis of
catecholamines and on their content in the body. It also induces a
sedative effect, suppresses reflexes transmitted along the
sympathicus to the blood vessels. It is characterized by a broad
therapeutic index; reduces the peripheral vascular resistance;
decreases the intraocular pressure in glaucoma, slows down the heart
rate and reduces the stroke volume.
INDICATIONS:
Various forms of arterial hypertension, including renal
hypertension. All stages of hypertonic disease, particularly cases
resistant to other antihypertensives agents.
CONTRAINDICATIONS:
Pregnancy, patients with depression.
SIDE EFFECTS:
A considerable depression of psychic activity, lassitude, dryness in
the mouth with difficult swallowing and obstipation are observed at
the beginning of the treatment. Orthostatic hypotension can rarely
occur. The abrupt discontinuation of clonidine treatment can lead to
neuro-vegetative disturbances: enhanced nervous excitability,
headache, insomnia, nausea, vomiting, rarely elevated blood
pressure. |
PRECAUTIONS:
Alcohol is forbidden during Chlophazolin treatment. Drivers should
be warned about its sedative effect.
DRUG INTERACTIONS:
Simultaneous administartion with antidepressants and non-steroid
antiphlogistic agents can diminish the antihypertensive effect of
chlophazolin. The combined therapy of Chlophazolin with
beta-blockers can induce hypertonic crisis resembling the
deprivation syndrome after abrupt withdrawal of the drug. The
administration of high doses of neuroleptic and Chlophazolin leads
to potentiation of the sedative.
DOSAGE AND ADMINISTRATION:
Chlophazolin is effective even in low doses and the arterial
pressure should be followed up during treatment.
Orally: the treatment is initiated with 0.075 mg, 2-4 times daily,
in cases of insufficient effect the daily dose can reach up to
1.2-1.5 mg. The treatment lasts 1-2 months, whenever necessary - up
to 6-12 months.
In hypertonic crisis: 0.05-0,01 mg can be injected intramuscularly
or subcutaneously; intravenously - 0.05-0.01 mg (0.5-1 ml).
MEDICINAL FORM AND PACKAGE:
Packages with 10, 50 and 100 ampoules of 0.15 mg/l ml (0.015 %).
Packages with 50 tablets of 0.15 mg.
STORAGE:
At moderate temperature (15-30° C).
EXPIRY:
3 (three) years.
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