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PARACETAMOL
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| StockNo |
Product description |
| EB0280-421-10 |
PARACETAMOL
SYRUP FLASK 125 ML |
| EB0280-421-24 |
PARACETAMOL
SUPPOSITORIES CHILDREN 125 MG X 5 |
| EB0280-421-25 |
PARACETAMOL
SUPPOSITORIES ADULTS 250 MG X 5 |
| EB0280-421-26 |
PARACETAMOL
TABL 500 MG X 10 |
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- COMPOSITION:
Paracetamol
- 250 mg in 5 ml syrup
125 mg in a suppository for children
250 mg in a suppository for adult
500 mg in a tablet
ACTION:
Paracetamol belongs to the group of non-steroid antiinflammatory
drugs, inhibiting prostaglandin synthesis. As cyclooxzgenase
inhibitor, it is better than many of the drugs in that group. It
possesses a stronger analgesic effect, a weak antipyretic
effect, and a slightly manifested antiinflammatory effect. The
effect of Paracetamol is similar in strength, promptness and
duration to that of acetylsalicylic acid.
PHARMACOKINETICS:
Paracetamol is absorbed well after oral administration. Maximum
plasma levels are obtained between the 30th min and the 4th hour.
About 25% in bound to the plasma proteins, and its plasma half-life
is between 90 min and 2 hours. Paracetamol is metabolized to
glucuronides and sulphates in the liver. The urine concentration is
higher than the plasma concentration.
INDICATIONS:
Paracetamol is indicated for treatment of headache, neuralgia,
lumbago, sciatica, radiculitis, and rheumatic pains. It is used for
treatment of fevers. In a combination with other non-steroid
antiinflammatory drugs it is used for treatment of colds, fever and
inflammation.
CONTRAINDICATIONS:
Liver and renal insufficiency, and anemia with glucose-6-phosphate
dehydrogenase deficiency. |
SIDE EFFECTS:
Life threatening adverse effects: liver necrosis may appear in case
of a prolonged overdosing. Rarely it induces allergy, hypoglycaemia,
bronchospasm, haemolytis anemia.
PRECAUTIONS:
Paracetamol should be given cautiously to patients with a history of
alcoholism, acute liver disease, renal insufficiency,
hypersensitivity towards drugs, and to asthmatic patient (danger of
bronchospasm).
DRUG INTERACTIONS:
If taken together with alcohol, the toxicity of paracetamol is
increased. The effect of the drug is reduced by barbiturates, while
the risk of liver damage increases. The same is valid for
carbamazepine. Paracetamol increases the plasma levels of
chloramphenicol, and potentiates the effect of the cumarin
anticoagulants.
DOSAGE AND ADMINISTRATION:
Paracetamol is applied orally in doses of 0.5-1.0 g, 4 times daily
in adults, and 0.5 g, 3 times daily in children.
In the rectum: 1 g 1-3 times daily for adults; children between 1
and 5 years - 0.125 g, 1-3 times daily, the duration of the
treatment should not exceed 2 weeks.
MEDICINAL FORM AND PACKAGE:
Syrup in 125 ml flasks.
Suppositories of 125 mg and 250 mg in packs of 5.
Tablets in packs of 10.
STORAGE:
At room temperature (15-30° C).
EXPIRY:
3 (three) years.
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