ANALGIN
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| StockNo |
Product description |
| EB0280-421-02 |
ANALGIN
500 MG X 10 TABL |
| EB0280-421-15 |
ANALGIN
DROPS VIALS 10 ML |
| EB0280-421-16 |
ANALGIN
AMPOULE 1.0 G/2 ML |
-
- COMPOSITION:
Noramidopyrine methansulfonate sodium 1.0g/2ml in one ampoule;
50% solution and 500 mg in one tablet.
ACTION:
Analgin is a pyrazolone derivative with a strong analgesic,
antipyretic and spasmolytic activity. Its antiphlogistic
properties are less manifested. Compared to the narcotic
analgesics, it does not suppress the respiratory center even in
high doses, has no effect on intestinal peristalsis, does not
induce constipation and does not lead to habit-forming and
addiction. The mechanism of its analgesic action is associated
with the inhibition of the formation of allgogenic substances,
stimulation of non-piate antinociceptive system and inhibition
of prostaglandin synthesis.
PHARMACOKINETICS:
It is quickly and completely absorbed in the digestive tract,
metabolized in the liver to various metabolites, and only 3% of the
administered dose is excreted unchanged through the kidneys. Its
half-time in the blood is about 2.7 h.
INDICATIONS:
Acute and chronic pain accompanying the following diseases:
rheumatoid arthritis, headache, toothache,traumas, dysmenorrhea and
surgical intervention, strong pain associated with smooth muscles
spasms of the gastrointestinal tract, biliary ducts and urogenical
system, and for reducing the body temperature in febrile states.
CONTRAINDICATIONS:
Analgin must not be administered to patients with hypersensitivity
to pyrazolone derivatives, some metabolic diseases (hepatic
porphyria and comgenital deficit of glucose-6-phosphate
dehyrogenase). Its administration is contraindicated during the
first three months and the last 6 weeks of pregnancy, as well as to
children with a body weight below 5 kg.
SIDE EFFECTS:
The main side effects are due to the development of hypersensitivity
to the drug, the most important being shock and changes in the blood
count (agranulocytosis, leukopenia and thrombocytopenia). Transitory
disfunctions accompanied by oliguria, polyuria, proteinuria and
intestinal nephritis can originate in patients suffering from renal
diseases or after the administration of high doses. Urticarial
rashes and itching on the skin, mucosa and conjuctiva can rarely be
observed. Asthmatic paroxysms can be provoked in patients suffering
from asthma. |
PRECAUTIONS:
The existence of hypersensitivity of the patient to the drug must be
checked prior to analgin treatment. Blood pressure must be checked
during parental administration, particularly in patients with
circulatory instability and systolic arterial pressure under 100mg/
Hg.
DRUG INTERACTIONS:
The cyclosporine level in the blood plasma is reduced during
parallel administration of analgin and cyclosporine. Analgin and
alcohol have a reciprocal effect as regards their basic effects.
DOSAGE AND ADMINISTRATION:
Parenterally to adults (intramuscularly or slowly intravenously) -
2-5 ml, 1-4 times daily.
Children from 5 up to 8 kg - 0.1-0.2 ml
From 9 to 15 kg - 0.2-0.5 ml
From 16 to 30 kg - 0.3-1.0 ml
From 31 to 50 kg - 0.8-12.8 ml
1-4 times daily.
Orally to adults - 1 tablet or 20 drops from the solution, 1-3 times
daily.
Children: from 2 to 3 years - 0.05-0.10 g
From 3 to 5 years - 0.10-0.20 g
2-3 times daily.
The maximum daily dose for oral administration is 3 g, for
parenteral administration it is up to 10 ml injection solution.
MEDICINAL FORM AND PACKAGE:
Packages with 10, 50 and 100 ampoules of 1.0 g/2 ml.
Drops in vials of 10 ml.
Packages with 10 tablets.
STORAGE:
At moderate temperature (15-30° C), in a place protected from
light.
EXPIRY:
3 9three) years.
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