PHENOBARBITALUM

 

StockNo	Product description	Status
EB0280-410-19	PHENOBARBITALUM TABL 100 MG X 10
EB0280-410-44	PHENOBARBITALUM AMPOULE 100 MG/1ML
EB0280-410-45	PHENOBARBITALUM AMPOULE 200 MG/2ML
EB0280-410-46	PHENOBARBITALUM SYRUP 125 ML

 

COMPOSITION:
Phenobarbital 100 mg/1 ml; 200 mg/2 ml in one ampoule; 20 mg/in 5 ml syrup and 15 mg and 100 mg in one tablet.

ACTION:
Phenobarbital suppresses CNS and ahs a sedative hypnotic and anticonvulsive action, depending on the dose. Compared with other barbiturates, it inhibits more strongly the excitation of the motor centers of the brain, hence it is widely used in the treatment of epilepsy, chorea and spastic paralysis. As a sedative (usually in combinations), it is administered in low doses for the treatment of the initial stages of hypertonic disease and vascular spasms (migraine, angina pectoris). As a drug with acid character it has higher concentrations in the extracellular fluids. With the increase of pH values in the medium, the percentage share of the ionized part of phenobarbital abruptly increases. Its protein content is the highest in adults and the lowest in the fetus. Phenobarbital is one of the active enzyme inductors. The coefficient of its liver elimination (main pathway) is rather low; from 0.1 to 0.3. The analysis of urine leads to its intensive ionization and to enhanced excretion.

INDICATIONS:
Epilepsy, chorea, sleep disturbances. In small doses in hypertonic disease. It has a good effect on vascular spasms (migraine, angina pectoris).

CONTRAINDICATIONS:
Diseases of liver and kidneys, high temperature, allergy to barbiturates, the first three months of pregnancy.

SIDE EFFECTS:
The high doses can cause a suppression of respiration, vascular collapse, pulse deceleration; temperature decrease, reduction of diuresis; lassitude, apathy, ataxia, memory impairment, psychic disturbances, allergic reactions.

DRUG INTERACTION:
When administered with phenobarbital, the metabolism of certain drugs is accelerated, their effect becoming weaker and shortens. More than 60 chemical substances react in this way, among them anticoagulants, digitoxin, corticosteroids, many of the non-steroid antiphlogistic agents, theophyllin (phenomenon of "induction" of enzymes).

DOSAGE AND ADMINISTRATION:
In insomnia it is orally prescribed as a hypnotic drug, if the insomnia is associated with anxiety and excitation - adults: 0.1-0.2, a single intake in the evenings; children: 0.005-0.075 per intake, depending on age. In epilepsy it is administered twice daily - 0.05 with gradual increase of the dose, but not more than 0.6 g per 24 h; as a spasmolytic and sedative - 0.01-0.03 g, 2-3 times daily.

MEDICINAL FORM AND PACKAGE:
Packages with 10 and 50 ampoules of 100 mg/1 ml and 200 mg/2 ml.
Syrup in vials of 120 ml.
Packages with 30 tablets of 100 mg.

STORAGE:
At moderate temperature (15-30 C) in a place protected from light.

EXPIRY:
Ampoules and syrup - 3 (three) years.
Tablets - 5 (five) years.