GENTAMICIN
| StockNo |
Product description |
| EB0280-408-09 |
GENTAMICIN
AMPOULE 10 MG/1 ML |
| EB0280-408-23 |
GENTAMICIN
AMPOULE 20 MG/1 ML |
| EB0280-408-24 |
GENTAMICIN
AMPOULE 40 MG/1 ML |
| EB0280-408-25 |
GENTAMICIN
AMPOULE 80 MG/1 ML |
| EB0280-408-26 |
GENTAMICIN
VIAL 10 ML |
-
- COMPOSITION:
Gentamicin sulfate 10 mg/1 ml, 20 mg/l ml, 40 mg/1 ml, and 80
mg/2 ml in one ampoule and 1 % solution 10 ml.
ACTION:
Gentamicin is a broad-spectrum antibiotic from the aminoglycoside
group. It is isolated from the culture of Micromonospora purpurea,
var. violacea. It is effective against many Gram-positive and
Gram-negative microorganisms: Proteins, colibacteria, salmonellae,
shigellae, pasteurelleae, mycoplasms, gonococci, brucellae,
staphylococci, etc.
PHARMACOKINETICS:
Administered intramuscularly, it reaches the maximum serum
concentration after 30 to 60 min. it binds to plasma proteins from
25 to 80 % and its half-life is from 2.5 to 4 h. it is excreted
unchanged by glomerular filtration.
Gentamicin penetrates into the cerebrospinal fluid, peritoneal fluid
and transplacentally, reaching high concentrations in the urine.
INDICATIONS:
It is administered in case of uroinfections (acute and chronic
pyelonephritis) sepsis, pulmonary infections, secondary infected
burns, shigella and salmonella diseases, unspecific meningitis,
peritonitis, salpingitis, osteomyelitis, skin infections and
infections of the biliary ducts.
CONTRAINDICATIONS:
Hypersensitivity to gentamicin, during the first three months of
pregnancy. It should be administered cautiously in severe diseases
of the renal and hepatic parenchyma.
SIDE EFFECTS:
The most frequent and severe adverse effects are observed in
patients with disordered renal function, in advanced age and with
damaged acoustic nerve. Ototoxicity, nephrotoxicity (elevated blood
urea, residual nitrogen and reduced diuresis), allerigc reactions
can be observed, as well as muscle twitchings, convulsions,
headache, transotiry elevation of serum bilirubin and transaminases. |
PRECAUTIONS:
Skin sensitivity tests are recommended prior to the initiation of
the treatment.long-term administration of high doses should be
avoided and when necessary - the renal acoustic and vestibular
function should be followed up. Renal excretion of gentamicin is
delayed in newborn babies and is 17 % from that of adults.
DRUG INTERACTIONS:
The simultaneous administration of gentamicin with other
aminoglucoside antibiotics (kenamycin, stretomycin, neomycin),
polymixins cephalosporins, preparations of ethacrynic acid and
furosemide enhances the ototoxic risk. Gentamicin potentiates the
effects of myorelaxants (succinylcholine and tubocurarine),
resulting in intensification and prolongation of the neuromuscular
block.
DOSAGE AND ADMINISTRATION:
Adults with normal renal function - 2 to 4 mg/kg body weight,
divided and administered intramuscularly at 12 or 8 h respectively.
Children over 2 years, the maximum daily dose is 5 mg/kg body
weight, divided in 2-3 injections. For newborn infants the dose can
reach from 6 to 7 mg/kg body weight daily and should be reduced
immediately after the improvement of the condition. The treatment
course lasts from 5 to 10 days.
In sepsis - the antibiotic can be administered intravenously (very
slowly), diluted with 15-20 ml physiologic solution or 5 % glucose.
MEDICINAL FORM AND PACKAGE:
Packages with 10, 50 and 100 ampoules of 10 mg/l ml, 20 mg/l ml, 40
mg/l ml and 80 mg/l 2 ml, 10 ml in vials.
STORAGE:
At moderate temperature (15-30° C).
EXPIRY:
3 (three) years.
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