AMIKACIN
| StockNo |
Product description |
| EB0280-408-02 |
AMIKACIN
AMPOULE 100 MG/2 ML |
| EB0280-408-15 |
AMIKACIN
AMPOULE 250 MG/2 ML |
| EB0280-408-16 |
AMIKACIN
AMPOULE 500 MG/2 ML |
| EB0280-408-17 |
AMIKACIN
AMPOULE 1000 MG/4 ML |
-
- COMPOSITION:
Amikacin sulfate 100mg/2ml; 250 mg/2ml;
500 mg/ml; 100 mg/4 ml in one ampoule.
ACTION:
Amikacin is a semisynthetic aminoglycoside antibiotic with bacterial
type of action. It is active against various species of
gram-positive and gram-negative microorganisms: Staphylococcus
aureus (including those resistant to semi-synthetic penicillins), D.
pneumoniae, Streptococcus, Enterococcus, Proteus spp.
(indole-positive and indole-negative), Salmonella spp., Shigella
spp., Citobacter, Providentia. Its action against Ps. Aeruginosa
(resistant to gentamycin), Klebsiella, Enterobacetr and Serratia is
particularly manifested.
PHARMACOKINETICS:
It is quickly absorbed, creating high serum and tissue
concentrations. Its binding to plasma proteins is insignificant.
Amikacin readily penetrates in tissues, crosses the placental
barrier and diffuses into the pleural and amniotic fluid. It is
exercised unchanged with the urine through glomerular filtration:
about 90% within 24 h. it is less toxic than gentamycin and
tobramycin.
INDICATIONS:
Treatment of severe infections: respiratory - pneumonia,
bronchopneumonia, empyema, etc.; septic states of various origin;
urogenital infedctions - acute and chronic pyelonephritis, cystitis,
prostatitis, endometritis, parametritis, etc.; infections of the
skin and soft tissues, postoperative infections of wounds;
infections of bones and joints - osteomyelitis, septic arthritis,
bursitis, etc.; gastrointestinal infections: dysentery,
salmonellosis, etc.
CONTRAINDICATIONS:
Hypersensitivity to aminoglycoside antibiotics and pregnancy.
SIDE EFFECTS:
Very rarely - allergic reactions, skin rashes, headache,
paresthesia, nausea and vomiting. Damage of the vestibular and
cochlear nerve could be observed after long-term treatment with high
doses, and in very rare cases - damage of the renal function. |
PRECAUTIONS:
Sufficient amounts of liquids should be taken during amikacin
treatment, and in patients with disturbed renal function the
creatinine serum level should be checked periodically.
DRUG INTERACTIONS:
The combined administration of amikacin with cephalosporins enhances
the nephrotoxicity of aminoglycosides. Combination with diuretics
leads to increase of its oto- and nephrotoxicity. With halothane,
methoxyfluran and curare-like agents, the neuromuscular blockade is
intensified.
DOSAGE AND ADMINISTRATION:
It is parenterally administered, intramuscularly and intravenously.
It should be administered slowly (for 2 min) when injected
intravenously. The infusion to children and adults should last from
30 to 60 min, in newborn babies - 1 to 2 h. the mean daily dose for
adults id from 250 to 500 mg, for breast-fed babies and children -
from 10 to 15 mg per kg body weight, divided into two equal doses
every 12 h. the duration of a treatment course with intramuscular
administration is from 7 to 10 days, and with intravenous
administration - from 3 to 7 days. Amikacin, in a concentration of
0.25%, can be applied successfully for lavage of abscess cavities,
pleural cavity and peritoneum.
MEDICINAL FORM AND PACKAGE:
Packages with 100 ampoules of 100 mg/2 ml; 250 mg/2 ml and 500 mg/2
ml.
Packages with 50 ampoules of 1000 mg/4 ml.
STORAGE:
At moderate temperature (15-30° C) in a place protected from direct
sunlight.
EXPIRY:
2 (two) years.
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