EDTA-CALCIUM-DINATRIUM
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| StockNo |
Product description |
| EB0280-401-04 |
EDTA-CALCIUM
DINATRIUM AMPOULE 10 ML 10% SOLUTION |
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- COMPOSITION:
Calcium disodium edetate 10 % ml solution in one ampoule
ACTION:
Antidote. The disodium salt of EDTA-calcium is a compound from the
group of complexons and forms stable water-soluble complexes with
the ions of heavy and rare metals, which are less toxic and quickly
excreted with the urine. About 60-90 % of the drug is excreted after
6 h and up to 95% after 24 h. Calcium, included in the composition
of the drug, is substituted by more stable ions and metals (lead,
throium, etc.) but not by barium and stontium, etc.
Besides as an antidote the drug is used as a calcium agent in
hypofunction of the parathyroid gland, hypocalcemia, etc.
INDICATIONS:
Acute and chronic intoxications with heavy and rare metals and their
salts: lead, mercury, cadmium, uranium, copper, cobalt, manganese,
chromium, gold, zinc, etc.; lead encephalopathy in children;
intoxication with tetraethyl and ethylated benzine; contamination of
the organism with radioactive metals; as calcium drug in
hypofunction of the parathyroid gland, osteomalacia and other
diseases associated with hypocalcemia.
CONTRAINDICATIONS:
Severe damage of kidneys (nephritis, nephrosis), liver diseases with
disordered function. |
SIDE EFFECTS:
Toxic reactions have been observed with a dose of 2 g or more,
daily. It causes toxic nephropathy, reduces the blood hemoglobin and
the iron level in the serum, as well as the lever of vitamin B12. To
avoid these injuries, vitamin B12 is recommended to be included in
the treatment and iron-containing drugs - in case of long-term
administration.
DOSAGE AND ADMINISTRATION:
An antidote in intravenous drip infusion - 1 g from the drug (one
ampoule 10 % 10 ml) in 250-500 ml sterile physiological solution or
5% glucose solution, with duration of the infusion one hour. This
dose can be administered twice daily for 3-4 days, followed by a
2-day rest. Whenever necessary, another course of 3-4 days can be
performed. The maximum daily dose for adults is 2 g, administered
twice daily in intakes of 1 g; mean therapeutic dose - 0.02g/kg
weight. For children - single daily dose not more than 0.5 g (5 ml
10 % solution) per 15kg body weight, twice daily. Gastric lavage is
performed before and after the intake in case of oral administration
of the antidote.
MEDICINAL FORM AND PACKAGE:
Solution 10% 10 ml, in packages with 25 and 50 ampoules.
STORAGE:
At moderate temperature (15-30° C).
EXPIRY:
5 (five) years.
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