VITAMIN K3

StockNo	Product description
EB0280-101-24	VITAMIN K3 AMPOULE 10 MG/1ML 1%

 

COMPOSITION:
Menadione 10 mg/1 ml in one ampoule

ACTION:
Vitamin K3 is a synthetic analogue of Vitamin K. The advantage of the drug is its water-solubility which determines its use as an agent of choice in Vitamin K deficiency caused by "malabsorption " syndrome, cholestatis, etc. The drug is necessary for prothrombin biosynthesis in the liver, the enhancement of prothrombin in blood plasma and blood coagulability. It is necessary for the biosynthesis of some factors of blood coagulation - factor II (prothrombin), factor VII (proconvertin), factors IX and X. Its action is manifested in hypoprothrombinemia but in some cases also in normal prothrombin level in the blood. The effect of the drug is attained 2-3 days after its administration, because the process of influencing the hepatic enzyme system is slow.

INDICATIONS:
Insufficient production of Vitamin K in the large intestine as a result of absence of colibacteria; disturbances of fat absorption due to obstruction of biliary ducts or other causes for the inflow of small quantities of bile into the intestines; hemorrhagic diathesis, mainly on the base of hypoprothrombinemia; prophylactically - prior to and post operations for avoiding bleeding; therapeutically - in hypothrombinemia of newborn and prematurely born infants; overdosage and intoxication with dicoumarin and indandion anticoagulants. Tretment with broad-spectrum antibiotics and sulfonamides leading to destruction of the intestinal flora.

SIDE EFFECTS:
Vitamin K3 can enhance sensitivity to ionizing radiation. It can cause flushing on the face and pain at the injection site.

PRECAUTIONS:
Vitamin K3 should be doses very cautiously during the period of childbirth and for newborn babies, because overdosage can cause kernicterus in infants.

DOSAGE AND ADMINISTRATION:
Parenterally: (intramuscularly and subcutaneously) - 10-20 mg daily. In severe cases, the dose can be increased to 50-100 mg daily (slowly intravenously).

MEDICINAL FORM AND PACKAGE:
Packages with 10 and 50 ampoules of 10 mg/1 ml (1 %).

STORAGE:
At moderate temperature (15-30° C), in a place protected from light.

EXPIRY:
2 (two) years.