VITAMIN C

StockNo	Product description
EB0280-101-21	VITAMIN C AMPOULE 200 MG/2 ML (10%)
EB0280-101-37	VITAMIN C AMPOULE 500 MG/5 ML (10%)

 

COMPOSITION:
Ascorbic acid 200 mg/2 ml; 500 mg/5 ml
in one ampoule.

ACTION:
Ascorbic acid has an effect on the intracellular oxidative-restorative processes and on the tissue respiration. It increases the synthesis of specific antimicrobial antioxins by improving the function of reticuloendothelial bodies. It reduces the permeability of marginal membranes, making the capillaries more compact and promoting the restriction of exudative, inflammatory and partially of allergic reactions; it has a desensitizing effect on the organism. Its antipermeability action is enhanced by Vitamin P (rutin and other bioflavonoids). It has a hemostatic effect. Stimulates the synthesis of corticosteroids. Improves the appetite and stimulates the growth of the young generation. It favors the formation of collids which maintain the structure of the bones, teeth, muscles and blood vessels. There is evidence that it can prevent the advancement of atherosclerosis. It is intensively spent during febrile states.

PHARMACOKINETICS:
Ascorbic acid is absorbed quickly and completely, mainly in the proximal segment of the small intestine. It is evenly distributed in the tissues of the body. It is metabolized to dehydroascorbic, 2-3-diketogulonic and oxalic acid in the liver. When the concentration gradient in the plasma exceeds 1.4 mg per 100 ml, the ascorbic acid is eliminated with the urine. The administration of doses of 2 and 4 g daily is not associated with the increased quantity of oxalates in the urine. Only with a dose of 9 g daily a significant increase of oxalates in the urine of healthy volunteers has been established about 95 mg for 24 h.

INDICATIONS:
In hemorrhagic diathesis due to enhanced fragility of the capillaries: for improvement of the general resistance of the body to local and general infections, pertussis, scarlet fever, diphtheria, pneumonia, etc.; drug and intestinal intoxications, refractory wounds and fractures, in dental caries; pregnancy and breast-feeding, toxicosis of pregnancy, dermatitis; Basedow's disease, diabetes, hypertonic disease; stomatitis.

SIDE EFFECTS:
Administered in a dose of 5-10 g daily, Vitamin C can cause gastrointestinal discomfort.

DRUG INTERACTIONS:
Vitamin C interacts with the tests for quantitative determination of glucose and urine, with the use of oxidation-reduction methods. Vitamin C administration should be discontinued 1-2 days prior to the tests. Ascorbic acid is not mixed in one syringe or infusion solution with ampicillin, carbencillin, cefalosporins, chloramphenicol, etc.

DOSAGE AND ADMINISTRATION:
Prophylactically - adults, 25-75 mg; to newborn babies - orally 6 mg/kg body weight but not exceeding 30-35 mg daily. In the presence of methemglobinemia in breast-fed infants and little children - doses between 500 mg and 1 g daily are recommended.
Therapeutically - the doses of adults should not be lower than 250 mg daily, divided into 3-4 intakes. In refractory wounds, infectious diseases and iron deficiency anemia - oral doses of half to one gram daily are recommended. Doses of 1-2 g daily, intravenously, are recommended for prophylaxis of surgical shock.

MEDICINAL FORM AND PACKAGE:
Packages with 10, 50 and 100 ampoules of 200 mg/2 ml (10 %).
Packages with 10 and 50 ampoules of 500 mg/5 ml (10 %).

STORAGE:
At moderate temperature (15-30° C), in a place protected from direct sunlight.

EXPIRY:
2 (two) years.