VITAMIN B12

StockNo	Product description
EB0280-101-34	VITAMIN B12 AMPOULE 100 GAMMA 1 ML
EB0280-101-19	VITAMIN B12 AMPOULE 250 GAMMA 1 ML
EB0280-101-25	VITAMIN B12 AMPOULE 500 GAMMA 1 ML
EB0280-101-26	VITAMIN B12 AMPOULE 1000 GAMMA 1 ML

 

COMPOSITION:
Cyancobalamin 100 gamma/1 ml; 250 gamma/1 ml; 500 gamma/1 ml; 1000 gamma/1 ml in one ampoule.

ACTION:
Vitamin B12 is a catalyst of protein metabolism. Promotes the synthesis of proteins by participating in the synthesis of compounds with mobile methyl groups, such as choline, methionine and nucleic acids of nuclei. It stimulates erythropoiesis by promoting the synthesis of hemoglobin and accumulation in the erythrocytes of compounds with sulfhydryl groups. It is introduced as "external factor" in the body with the food and is synthesized by the intestinal flora. It has a favorable effect on the function of liver, nervous system, in addition to its antiallergic action. Vitamin B12 prevents the progress of pernicious anemia.
Vitamin B12, administered parenterally, binds to a specific beta-globulin (transcobalamin II), performing transport functions, and to alpha-globulin (transcobalamin I), having mainly a deferring significance. Between 1 and 10 % of the introduced dose are in free form. The mean concentrations in the plasma amount are 450 pg/ml (from 200 to 900 pg/ml). Liver is the main depot of Vitamin B12 in the body.

PHARMACOKINETICS:
The half-elimination time of the vitamin in the blood plasma is 5 to 14 days, in the hepatic tissue - about one year. With the introduction of an initial dose of 50 mkg, about 95 % is retained in the body, whereas in doses of 100-1000 mkg, about 50 to 90 % are eliminated within the following 48 h.

INDICATIONS:
Pernicious anemia, pernicious-like anemias; nutritional macrocytic anemia due to vitamin B12 deficiency in case of damage of the gastrointestinal tract and liver, sprue, macrocytic anemia in pregnant women (together with Vitamin C), neuralgia, neuritis, allergic diseases.
Substitutive therapy with Vitamin B12 is recommended for patients on a vegetarian diet, with chronic alcohol consumption or on oral contraceptives.

SIDE EFFECTS:
The drug is well tolerated. Allergic reactions are likely to occur, though exceptionally rarely. Hypervitaminosis B12 has not been reported so far.

DRUG INTERACTIONS:
Some drugs, notably phenobarbital, phenytoin and pyramidon, intensify Vitamin B12 metabolism and lead to hypovitaminosis. Vitamin B6 and B1 must not be mixed in one syringe with vitamin B12 or with infusion solution of Vitamin B12.

DOSAGE AND ADMINISTRATION:
In pernicious anemia and in all B12 folic acid deficiency anemias - in doses of 30-50 gamma, 2-3 times weekly (intramuscularly). In more severe forms - 300-500 gamma, once weekly. For the maintenance of a compensated pernicious anemia - 20-30 gamma every second day. In neuralgia, neuritis, psoriasis - 250-500-1000 gamma, 2 times weekly, or every second day, or every day depending on the severity of the disease.

MEDICINAL FORM AND PACKAGE:
Packages with 10, 50 and 100 ampoules of 100 gamma/1 ml, 250 gamma/1 ml, 500 gamma/1 ml and 1000 gamma/1 ml.

STORAGE:
At moderate temperature (15-30° C), in a place protected from direct sunlight.

EXPIRY:
2 (two) years.