International generic name Bromhexin hydrochloride
Drug form and composition Bromhexin hydrochloride: 4 mg/2 ml in one ampoule; 2 mg in 1 ml solution and
4 mg in 5 ml syrup.
Indications All forms of tracheobronchitis; emphysematous bronchitis, bronchiectasis with inflammatory pulmonary diseases. Prior to and after surgical interventions with general anesthesia, particularly in elderly patients. The drug has pronounced mycolytic and secretolytic activity. It has a soothing effect on cough and a slight emetic action. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres. It has no effect on intestinal peristalsis. It is quickly absorbed in the gastrointestinal tract and excreted with urine.
Dosage and administration In adult patients is administered 10 ml syrup, 3-4 times daily. In children older than 10 years the dosage is 10 ml, 3 times daily, and in children from 3 to 10 years - 5 ml, 3 times daily.
Contraindications Hypersensitivity to the drug.
Special warnings and precautions Transitory gastrointestinal disturbances, perspiration. Irritation with cough is likely to occur during inhalation. The adverse effects are transient. In single cases, it can induce short-term elevation of serum transaminase.
Dosage and administration Orally: adults - 4 ml of the solution, 3 times daily.
Children from 5 to 10 years - 2 ml 3-4 times daily; under 5 years - 20 drops, 3 times daily. Ten drops can be given to breast-fed infants, 2-3 times daily.
The treatment usually lasts 3-5 weeks (rarely months) for adults, being considerably shorter for children.
Parenterally: 1 ampoule 2-3 times daily is prescribed in severe cases, to be injected s. c., i. m. or i. v., but very slowly (for 2-3 min).
Inhalation: the solution is diluted with distilled water in a ration of 1: 1 and inhaled: adults, 2 ml 2-3 times daily (with warmed solution); children, 5-10-20 drops, 1-2 times daily, depending on age. The inhalation can be combined with oral intake of the preparation, which can enhance its action.
Supplied Packages with 10, 50 and 100 ampoules of 4 ml/2 ml (0.2 %).
Solution 0.2 % in vials of 40 ml.
Syrup 0.08% in vials of 125 ml.
Expiry 3 years. |