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  Nivaliln (Galantamine)
 Nivalin introduction
 Nivalin (Galantamine) is the result of a natural product
 Nivalin (Galantamine) and the adrenals
 Nivalin pharmacokinetics
 Safety and Toxicity studies
 Mutagenicity of Nivalin (Galantamine)
 Clinical application of Nivalin
 References
 Table of Contents
 Galantamine HBr
Nivalin (Galantamine) is an original phytopreparation developed by Sopharma's own research team and produced with an original technology for extraction of the alkaloid Galantamine from the bulbs of the plant snowdrops (Leucojum aestivum).
 

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  nivalin home /
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Nivabex syrup  
 
Galantamine)

Nivabex syrup GalantamineCOMPOSITION OF ONE TEASPOON:
Galantamine hydrobromide 2.5 mg
Thiamine chloride (Vitamin B1) 7.5 mg
Riboflavin – phosphate natrium (Vitamin B2) 3 mg
Pyridoxine hydrochloride (Vitamin B6) 5 mg
Nicotinamide (Vitamin PP) 25 mg
Calcium pantothenate 25 mg

ACTION
Nivabex is a combination of Nivalin (Galantamine) and B group vitamins. Its pharmacological action is expressed in improvements of the functional activity of the nervous system and metabolite processes in the body.

Nivalin is a strong reversible inhibitor of the cholinesterase stimulating nerve impulses in the neuromuscular synapses and the synapses of the Central and Peripheral nervous systems.

Vitamin B1 following its transformation in pyrophosphate as a coenzyme participates in the metabolism of the carbohydrates, proteins and the synthesis of nucleonic acids. It facilitates the transmission of the action potentials in the peripheral nerves and the neuromuscular transmission.

Vitamin B2 is included in the composition of many oxidative enzymes and participates in the metabolism of carbohydrates, proteins and fats. It plays important role in the normal functions of the eye, ligaments and skin.

Vitamin B6 in the body is transformed into pyridoxal phosphate and plays the role of coenzyme in multiple enzyme reactions.

Vitamin PP (Nicotinic acid and Nicotinamide) is included in the composition of codehydrogenases, participates in the enzyme reactions of dehydration. Improves the functions of the skin and mucosa, avoids the origination of pellgra and other lesions of the skin, gastrointestinal disorders and damage of the nervous system. It intensifies the detoxification function of organism and has a vasodilatory action.

Calcium pantothenate is included in the coenzyme A and participates in the metabolism of carbohydrates and lipids in the synthesis of steroidal hormones and acetylcholine, as well as in the energy facilitation of the compensating functions of the myocardium.

Nivabex possesses activity that is expressed in:

  • Improvement of the condition of the nervous system
  • Antagonizing action with respect to various agents with damaging effect on the nervous system
  • Anti-inflammatory and analgesic action

INDICATIONS:
Poliomyelitis - immediately after bringing down the temperature during both restorative and residual periods. Myasthenia, myopathies, motor and sensory disturbances connected with diseases and traumatic injuries of the nervous system, polyneuritis, radiculitis, radiculoneuritis, myelitis; after-effects of diseases of the cerebral vessels; lower tone of the smooth muscles of the gastrointestinal and urinary tracts.

CONTRAINDICATIONS:
Bronchial asthma, bradycardia, stenocardia, cardiac decompensation, epilepsy, hyperkinesias

SIDE EFFECTS:
In adequate doses, the preparation is well tolerated. Overdosage and individually increased sensitivity may cause abundant salivation, perspiration, vomiting or dizziness. If such symptoms appear, the daily dose is reduced or the treatment is discontinued for 2-3 days, to be continued later with lower doses. If necessary, atropine may be used as an antidote.

APPLICATION AND DOSAGE:

Children
1 to 2 years: 2 times daily ½ teaspoon.
3 to 5 years: 2 times daily 1 teaspoon
6 to 8 years: 3 times daily 1 teaspoon
10 to 14 years: 4 times daily 1 teaspoon

 

Children above 14 years of age and adults 3 times daily 2 teaspoons.

The preparation has to be taken 1 hour after meal.

The treatment course continues 50 to 60 days. After an interval of 1 to 1 ½ months the treatment could be renewed and continued depending on the severity of the disease.

MEDICINAL FORM AND PACKAGE:
Glass vials of 125 ml

STORAGE:
In the original vial in a dry and light protected place at temperatures of 15-25°C

EXPIRY:
Two (2) years.

 

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