Nivalin®
(Galantamine)
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ALKALOID WITH
ANTICHOLINESTERASE ACTIVITY |
Excessive Decurarizing Drug
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Nivalin is an original
phytopreparation developed by Sopharma's own research team and
produced with an original technology for extraction of the alkaloid
Galantamine from the bulbs of the plant snowdrops (Leucojum
aestivum). Galantamine is the active ingredient in Nivalin.
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| Nivalin is competitive reversible inhibitor of
Acetylcholinesterase (AChE) and prolongs the hydrolysis of
endogenous mediator acetylcholine, thereby increasing its
accumulation in the choline sensitive postsynaptic membranes. |
Adaptation of nicotine cholinesterase transmission for account of
the blockage of AChE and the sensibilization of nicotine
acetylcholine receptors (nAChR).
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| ANTICHOLINESTERASE
ACTIVITY |
- Nivalin inhibits reversibly brain, erythrocytic, muscle and
serum cholinesterase. Its effect on brain cholinesterase is
10-12 times as potent, compared to physostigmine, since Nivalin
crosses the blood-brain barrier.
- Nivalin increases the intensity of nerve impulses leading to
the muscle tissues, increases muscle contractions and their
duration.
- Nivalin antagonizes the effect of nondepolarizing
neuromuscular blocking drugs. The antagonistic effect develops
20-30 s following parenteral administration and continues 30 to
60 minutes.
- Nivalin stimulates the frequency and tone of the
gastrointestinal muscle contraction.
- Nivalin possesses mild hypotensive effect when administered in
small or medium doses and in higher doses has two-phase action.
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| IN
NEUROLOGY NIVALIN IS APPLICABLE IN: |
- Poliomyelitis (immediately after the febrile period and during
the recovery and residual period.
- Neuritis, myopathies, myasthenia, progressive muscular
dystrophy, cerebral paralysis in childhood, cerebral palsy in
neonates. Enuresis nocturna
- Residual paresis following haemorrhagic stroke.
- Alzheimer's disease in light and medium stages.
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| NIVALIN
IS APPLICABLE AS WELL IN: |
- To abolish the effects of nondepolarizing neuromuscular
blockers and to treat postoperative paresis and bladder
complications.
- In some forms of impotence.
- In mental retardation.
- In poisoning with morphine and its analogues.
- In functional diagnostics of the gastrointestinal tract
(cholecystography and cholangiography.
- In electrophoresis in neuritis of the auditory, facial and
other nerves; neuritis, neuropathy, endarteritis obliterans,
angioneurosis, acrocyanosis, dyshidrosis and neurodermitis.
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| RECOMMENDED
DOSAGE SCHEMES: |
Nivalin is administered subcutaneously (s.c.), intramuscularly
(i.m) and intravenously (i.v.). Nivalin tablets are applied after
meals. The maximum single daily dose for adults is 15 mg s.c., and
maximum divided daily dose is 20 mg.
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Ampoules |
Tablets |
|
Age |
Appropriate doses |
Appropriate doses |
| From 1 to 2 years: |
0.25 - 1.0 mg |
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| From 3 to 5 years: |
0.50 - 5.0 mg |
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| From 6 to 8 years: |
0.75 - 7.5 mg |
5 - 10 mg |
| From 9 to 11 years: |
1.00 - 10.0 mg |
5 - 15 mg |
| From 12 to 15 years: |
1.25 - 12.5 mg |
5 - 25 mg |
| Over 15 yeas of age: |
12.50 - 15.0 mg |
10 - 40 mg |
A treatment course continues for 1 - 2 months and in degenerative
diseases of the Central Nervous System up to one year.
Nivalin is a preparation
with low toxicity, soft and stable action and possesses wide
spectrum of application for therapeutic purposes.
Nivalin is very well tolerated and despite that
fact should not be prescribed in conditions of bronchial asthma,
bradycardia, angina pectoris, heart failure, epilepsy, hyperkinetic
dyskinesia.
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| SOPHARMA
OFFERS NIVALIN IN THE FOLLOWING FORMS: |
- Ampoules of 1 ml in the concentrations of 1 mg; 2.5 mg; 5 mg
and 10 mg
- Tablets in concentrations of 5 mg in package of 60 count and
10 mg in package of 20 count.
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Galantamine hydrobromide
specifications [www.nivalin.com]
Galantamine Nivalin
ampoules 1 mg [www.nivalin.com]
Galantamine Nivalin tablets 5 mg
[www.nivalin.com]
Galantamine Nivalin
ampoules 5 mg [www.nivalin.com]
Galantamine Nivalin
ampoules 10 mg [www.nivalin.com]
Galantamine Nivalin
ampoules 2.5 mg [www.nivalin.com]
Galantamine NIVABEX SYRUP W/ VIT B
125 ML [www.nivalin.com]
Galantamine Nivalin tablets 10
mg [www.nivalin.com]
Captured link at www.nivalin.com
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine Nivalin and the
adrenals [www.nivalin.com]
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine Clinical application
of Nivalin (Galantamine) [www.nivalin.com]
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine hydrobromide
specifications [www.nivalin.com]
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine Nivalin
Anticholinesterase inhibitor Alzheimer neuromuscular diseases blood-brain
barrier cholinesterase
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine Nivalin
Introduction [www.nivalin.com]
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine Mutagenicity of
Nivalin (Galantamine) [www.nivalin.com]
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine Nivalin is the result
of a natural product [www.nivalin.com]
Galantamine NIVABEX SYRUP W/ VIT B
125 ML [www.nivalin.com]
Galantamine Nivalin ampoules 1
mg 2.5 mg 5 mg 10 mg x 1 ml [www.nivalin.com]
Galantamine Nivalin tablets
1, 5, 10 mg [www.nivalin.com]
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine How to order Nivalin
(Galantamine)? [www.nivalin.com]
Galantamine, Nivalin,
Alzheimers disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine
Pharmacokinetics of Nivalin (Galantamine) [www.nivalin.com]
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine Nivalin references
[www.nivalin.com]
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine Safety of Nivalin
(Galantamine). Toxicity Studies. [www.nivalin.com]
Galantamine, Nivalin, Alzheimers
disease, reversible acetylcholinesterase, cholinesterase inhibitors,
neuromuscular, nondepolarizing neuromuscular blockers, muscle contractions,
muscular dystrophy
Galantamine Nivalin table of contents
[www.nivalin.com]
Galantamine Nivalin
Anticholinesterase inhibitor Alzheimer neuromuscular diseases blood-brain
barrier cholinesterase
© 1999-2001 Sopharma
AD. All rights reserved. Nivalin is a
registered trademark of Sopharma AD in Bulgaria, trademark or registered
trademark of Sopharma AD in other countries. All other trademarks
appearing on this site are trademarks or registered trademarks of their
respective companies. All trademarks are subject to the domestic laws in
the respective countries. The Nivalin trademark is subject to the
pertaining international, bilateral and multilateral agreements as they
may apply in various countries or is subject to common law practices as
applicable in individual countries. |
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